Health Blog
Today : 23 May 2019, Thursday
Medical Terms Dictionary

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Male Contraceptive Compound Stops Sperm Without Affecting Hormones, was displayed 41 times.
Readable in 3 minutes

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Male contraceptive compound stops sperm without affecting hormones: Study in monkeys
In preclinical tests, researchers have shown how a new compound can immobilize sperm temporarily without side effects.

A new study published today in the journal PLOS ONE details how a compound called EP055 binds to sperm proteins to significantly slow the overall mobility of the sperm without affecting hormones, making EP055 a potential "male pill" without side effects.

"Simply put, the compound turns-off the sperm's ability to swim, significantly limiting fertilization capabilities," said lead investigator Michael O'Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine, and president/CEO of Eppin Pharma, Inc. "This makes EP055 an ideal candidate for non-hormonal male contraception."

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Currently, condoms and surgical vasectomy are the only safe forms of birth control currently available for men. There are hormonal drugs in clinical trials that target the production of sperm, but these affect the natural hormones in men much like female contraceptives affect hormones in women.

During the study, thirty hours following a high-dose intravenous infusion of EP055 in male rhesus macaques, O'Rand and researchers in the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no indication of normal sperm motility. Further, no physical side effects were observed.

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

"At 18 days post-infusion, all macaques showed signs of complete recovery, suggesting that the EP055 compound is indeed reversible," said study co-investigator Mary Zelinski, PhD, research associate professor at the ONPRC at OHSU and associate professor of obstetrics and gynecology in the OHSU School of Medicine.

O'Rand and Zelinski indicate that more work is needed before EP055 becomes available for human use. They and their teams have begun to test a pill form of the compound and will eventually conduct a mating trial of EP055's effectiveness against pregnancy.

Source: Shared by Katalay.net - Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Facebook Comments

Top Search Medical Terms

Abdominal Surgery : Surgery branch, abdominal surgery;Any procedure involving an incision into the abdomen. Laboratory, radiographic and cardiac tests and consultations can be perf...

Absolute Zero : Absolute ZeroThe theoretical temperature at which substances have no thermal energy is 0 K, -273.15 ° C or -459.67 ° F.(General Physics) the lowest theoreticall...

Abdominal Examination : The physical assessment of the abdomen of a patient by visual examination, auscultation, percussion and palpation. Visual examination of the normally oval shape...

Accident : Accident, an unforeseen occurrence, especially one of an injurious nature.cerebral vascular accident (cerebrovascular accident (CVA)) stroke syndrome.

Accessory Panceratic Duct : Accessory Panceratic Duct the excretory duct of the head of the pancreas formed from the proximal part of the duct of the embryonic dorsal pancreatic bud, that ...

Recent Articles

Most Read Articles

Top 10 Antiviral HerbsTop 10 Antiviral Herbs
630

Popular Articles

Şifalı BitkilerBinance.com
With donations you can help us

BTC: 1JUHtod758V2Bs5jxzB5pDhyBoEa9emxga

BCH: qzzxnc29asvfnla8q4ytxkfcvdjudxxjtumh8vemk4

ETH: 0x891280E6B1F1A9b9A195276eD9A9344da273E88a

LTC: LTzycFNc3JhWT7eUNKvSfM8Zay8BZwTrGY

VIA: VhAnvBdBhrPUzCGzCKbR9DwkFDJcUx7qoX

Health Blog (katalay.net)Medical Terms (katalay.org)